Achlorhydria by ezrin knockdown

Achlorhydria by ezrin knockdown

Loss of gastric acid secretion is pathologically known as achlorhydria. Acid-secreting parietal cells are characterized by abundant expression of ezrin (Vil2), one of ezrin/radixin/moesin proteins, which generally cross-link actin filaments with plasma membrane proteins. Here, we show the direct in vivo involvement of ezrin in gastric acid secretion. Ezrin knockout (Vil2(-/-)) mice did not surv...

Achlorhydria and Anæmia

PPI Network Analysis of mRNA Expression Profile of Ezrin Knockdown in Esophageal Squamous Cell Carcinoma

Ezrin, coding protein EZR which cross-links actin filaments, overexpresses and involves invasion, metastasis, and poor prognosis in various cancers including esophageal squamous cell carcinoma (ESCC). In our previous study, Ezrin was knock down and analyzed by mRNA expression profile which has not been fully mined. In this study, we applied protein-protein interactions (PPI) network knowledge a...

Achlorhydria: hypergastrinaemia: carcinoids--a flawed hypothesis?

A dye-resin test for achlorhydria.

The use of resins as a basis for "tubeless test meals " has made the unpleasant experience of aspiration of gastric contents unnecessary in many cases. A substance incorporated in the resin is released in the stomach only in the presence of free hydrochloric acid. This substance is then absorbed into the blood and excreted in the urine. Originally quinine was used in the test, and estimated flu...